Tasmania's forests provide habitat for an array of mammals, including four threatened species, the Tasmanian devil, spotted tailed quoll, eastern quoll, eastern barred bandicoot and New Holland mouse. Formal reserves contribute to the conservation of these species at the landscape-scale, but such reserves are limited in extent and distribution. Furthermore, reliance on a ‘set-aside’ approach alone can result in intensification of land-use activities outside reserves and subsequent loss and fragmentation of habitat. Complementary measures are needed to conserve habitat for these species in areas outside reserves. Under state and federal legislation, threatened species must be considered when planning forest practices in Tasmania. Research on the ecology of the species has been used to inform the development of measures to mitigate the impacts of forestry practices. A decision support system provides forest planners with a way to assess the risk and obtain information on practical ways to reduce any impacts of the proposed operation on listed species. Both coupe-level and landscape-scale measures are recommended. Ongoing monitoring and review, involving both forest planners and threatened species specialists, has resulted in a practical and useful tool for planning. Habitat descriptions, potential range boundaries and a planning framework have also been developed to facilitate landscape-scale planning. Taking a multi-scaled approach to the conservation of habitats for wide-ranging threatened species is not easy. The ongoing success of such an approach depends on a high level of commitment to monitoring and adaptive management.